Protein kinases constitute an enzyme family that catalyzes the phosphorylation of proteins that play vital role in regulation of almost every process in cell. Abnormal protein kinase activity might result in or contribute to a variety of major diseases such as cancer, Alzheimer’s disease, and diabetes. Therefore, the compounds that are able to recognize and block the increased activity of protein kinases are needed. The research project focused on the development of a new strategy for synthesis of Haspin-selective high-affinity fluorescent probe by combination of the solid phase peptide synthesis and solution phase synthesis. As the fluorescent probe was synthesised, its binding .
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